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pentobarbital will reduce the extent or effect of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Effect of coadministering a robust CYP3A4 inducer with fedratinib hasn't been examined.pentobarbital will lessen the level or outcome of bexarotene by affecting hepatic/intestinal enzyme CYP3A4